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ABCs Of Aging,
Alzheimer's, Estrogen And Memory
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Research at Our Center
Staff at the center
have led and participated in research studies related to memory disorders and other
neurologic and psychiatric conditions. Our research has been presented both at national
and international meetings and has been published in numerous
peer-reviewed journals.
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OUR RESEARCH
Research on memory loss in menopause:
In addition to presenting papers at both the 2000 and 2001
meetings of the North American Menopause Society, Dr. Devi was
the principal investigator in a study on treating memory loss in menopause.
Research on genetics of memory disorders: Children and
siblings of patients with Alzheimer’s, in addition to dealing with the trauma of this
fact, may also be concerned about risk for themselves. The research in this area helps
with genetic counseling for persons at risk for developing illnesses like
Alzheimer’s. Institution of preventive treatments in high risk persons would be
significant. Such preventive treatment may be especially effective in women.
Women and memory: Women may be at higher risk to
develop memory disorders.
Diagnosis of a memory disorder &
accuracy of diagnosis: Making the correct diagnosis of memory problems is crucial in
terms of beginning treatment and determining prognosis.
History of Alzheimer’s disease:
The
past gives us clues to the future and a short biography of Dr. Alois Alzheimer gives hope
for the future.
The HIV virus, the brain and
mind: The virus has a preference for the brain & therefore causes brain illness.
Alcoholism and the brain: The influence of
alcoholism on brain activity.
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WOMEN AND MEMORY
Dr. Devi has done a significant amount of research on the vulnerability of women to memory
disorders, the causes and treatments available. Here are some of the published research
papers.
Devi G,
Hahn K, Massimi S, Zhivotovskaya, E. The
prevalence of memory complaints in a community
of peri-menopausal women.
J Gender Specific Medicine
(In Press)
Devi G, Hahn K. Screening for cognitive and depressive symptoms among
peri- and post-menopausal women. Presented at the North American
Menopause Society Annual Meeting October 2001, New Orleans LA.
Devi G, Marrero C. The effectiveness of cognitive rehabilitation for
memory and cognitive loss associated with menopause.
Presented at
the North American Menopause Society Annual Meeting September 2000, Orlando,
FL.
Devi G. Estrogen in Alzheimer’s Disease.
Primary
Psychiatry 1997; 4(10):58-63.
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GENETIC STUDIES
This research helps us counsel relatives of patients on their risk for memory disorders.
Our genetic counseling program is geared towards the children and relatives of patients
with Alzheimer's and other neurodegenerative dementing illnesses. We discuss the risks of
inheriting the illness given the unique factors in the patient, such as age at onset of
illness, kind of symptoms, family history of other illness and personal medical history.
Often, given information that illnesses such as Alzheimer's are heritable, children may
fear developing the illness themselves. In fact, the vast majority of cases of Alzheimer's
are not inherited. Children of patients may be at increased risk in some instances and
risk may not be much higher than children of unaffected parents in others.
This level of informed discussion is useful to family members to help address their
unspoken (and, in may cases, unfounded) fears, and to help in planning for the future.
Additionally, in individuals at higher risk for developing the illness, prevention
strategies will be discussed.
Devi G,
Williamson J, Ottman R et al. Early onset
Alzheimer’s disease and familial co-aggregation
with psychiatric disorders.
J. Neuropsychiatry Clin Neurosci.Winter 2004; 16(1): 57-62.
Devi G, Ottman R, Tang MX et al. Familial aggregation of
Alzheimer’s Disease among Caucasians, African Americans and Caribbean Hispanics in
Northern Manhattan. Archives of Neurology 2000;57;72-77.
Devi G, Ottman R, Tang MX, et al. Influence of the APOE genotype on
familial aggregation of Alzheimer’s disease among Caucasians, African Americans and
Caribbean Hispanics in Northern Manhattan. Neurology 1999;53;789-784.
Devi G, Marder K, Schofield PW et al. Validity of family history for
the diagnosis of dementia among siblings of patients with late onset Alzheimer’s
Disease. Genetic Epidemiology 1998; 15:215-223.
Massoud F, Devi G, Goldman J, et al. Accuracy of clinico-pathologic
diagnosis of Alzheimer’s disease in clinic & community based patients (abstract).
Journal of Neuropsychiatry & Clinical Neurosciences 1998;11:139.
Presented at the annual meeting of the American Neuropsychiatric Association in February
1999.
Schofield P, Marder K, Dooneief G, Bell K, Chun M, Ramachandran G et
al. Subjective memory complaints predict decline in memory and cognition at 1 year
follow-up in individuals with cognitive impairment (abstract). Neurology
1996;46(suppl):434. Presented at the
American Neurologic Association’s annual
meeting in April, 1996.
Ramachandran G, Marder K, Tang M, et al. The Apolipoprotien E genotype
and psychiatric manifestations of Alzheimer’s disease. Neurology
1996;47:256-259.
Devi G, Ottman R, Tang M, et al. Familial aggregation of
Alzheimer’s disease and the influence of the APOE genotype among Caucasians, African
Americans and Caribbean Hispanics in Northern Manhattan (abstract). Annals
of Neurology 1998;44:396. Presented at the
American Academy of Neurology’s
annual meeting in October, 1998 in Montreal.
Devi G, Fotiou A, Gonzalez A, et al. Clinical features of very early
onset (ages 27-35) familial Alzheimer’s disease (abstract). Journal
of Neuropsychiatry & Clinical Neurosciences 1998;11:139. Presented at the
annual meeting of the American Neuropsychiatric Association in February, 1999.
Devi G, Fotiou A, Jyrinji D, et al. Novel presenelin 1 mutations
associated with early onset dementia in a family with both early-onset and late-onset
Alzheimer Disease. Archives of Neurology 2000;57:1454-1457.
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DIAGNOSIS OF
ALZHEIMER’S DISEASE
These studies help us in determining how accurate physicians are in making a diagnosis of
Alzheimer’s or a related dementia. Dr. Devi found in her research that when expert
guidelines are followed, clinical diagnosis of illnesses like Alzheimer's disease may be
made with over a 95% accuracy rate.
Devi G.
Motor Disorders in Dementia Syndromes.
Chapter in Textbook of Motor Disorders (2nd
Edition). David S. Younger, Ed. Lippincott
Williams and Wilkins, NY (In Press)
Devi G, Silver J. Approaches to memory loss in neuropsychiatric
disorders. Seminars in Clinical Neuropsychiatry. 2000;5:259-265.
Massoud F, Devi G, Stern Y, et al. A clinicopathological comparison of
community-based and clinic-based cohorts of patients with dementia.
Archives of Neurology 1999;56:1368-1373.
Massoud F, Devi G, Moroney J, et al. The role of routine laboratory
studies and neuroimaging in the diagnosis of dementia: a clinicopathological study
(abstract). Journal of the American Geriatric Society,
1999. Presented at the annual meeting of the American Geriatric Society.
Massoud F, Devi G, Goldman J, et al. Accuracy of clinico-pathologic
diagnosis of Alzheimer’s disease in clinic & community based patients (abstract).
Journal of Neuropsychiatry & Clinical Neurosciences 1998;11:139.
Presented at the annual meeting of the American Neuropsychiatric Association in February
1999.
Schofield P, Marder K, Dooneief G, Bell K, Chun M, Ramachandran G et
al. Subjective memory complaints predict decline in memory and cognition at 1 year
follow-up in individuals with cognitive impairment (abstract). Neurology
1996;46(suppl):434. Presented at the
American Neurologic Association’s annual
meeting in April, 1996.
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HISTORY OF ALZHEIMER’S
DISEASE
This research delved into the life of Alois Alzheimer, after whom the dementia was named.
A study of the past often provides insights for future directions.
Devi G, Quitschke W. Alois Alzheimer: His life and times.
Alzheimer
Disease and Associated Disorders Fall, 1999.
Devi G, Loreck R. Alois Alzheimer: Influential Alienist (abstract).
Neurology
1997;48:263. This research on Alois Alzheimer was presented at the
American Neurologic
Association’s annual meeting in April, 1997.
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NEUROLOGIC ILLNESS RELATED TO
THE HIV VIRUS
Because the HIV virus preferentially targets the brain, patients are more prone to brain
illness. In the following studies, Dr. Devi and colleagues investigate the harmful effects
of drugs in HIV patients, as well as the diagnosis and treatment of HIV dementia.
Ramachandran G, Glickman L, Levenson J, Rao C. The incidence of
extrapyramidal syndromes in hospitalized patients with AIDS and a comparison group.
Journal
of Neuropsychiatry and Clinical Neurosciences 1997;9:579-583.
Dana Consortium on the therapy of HIV dementia and related cognitive
disorders. Safety and tolerability of the antioxidant OPC14117 in HIV-associated cognitive
impairment. Neurology 1997;49:142-146.
Dana Consortium on the therapy of HIV dementia and related cognitive
disorders. Clinical confirmation of the American Academy of Neurology Algorithm for HIV-1
associated cognitive/motor disorder. Neurology 1996;47:1247-53.
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ALCOHOLISM AND THE BRAIN
Devi G.
Management of drug and alcohol withdrawal. N Engl J Med. 2003 Jul 24;349(4):405-7.
Ramachandran G,
Porjesz B, Begleiter H, Litke A. Cognitive
evoked potentials in young males at high risk
for alcoholism. Alcohol Clin Exp Res
1996;20(1):9-15.
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Please note that all material contained herein is provided for informational purposes
only and should not be considered as medical advice or instruction. Consult your health
care professional for advice relating to a medical problem or condition. Please also read
the disclaimer section.
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